ORY-1001 dihydrochloride |CAS:1431303-72-8 Probechem Biochemicals

Chemical Structure : ORY-1001 dihydrochloride

CAS No.: 1431303-72-8

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ORY-1001 dihydrochloride (Ladademstat dihydrochloride, RG-6016 dihydrochloride, ORY1001 dihydrochloride)

货号: PC-35458Not For Human Use, Lab Use Only.

ORY-1001 dihydrochloride (RG-6016, Ladademstat) is a highly potent, selective inhibitor of lysine-specific demethylase KDM1A (LSD1) with IC50 of 18 nM, displays high selectivity for KDM1A over other FAD-containing monoamine oxidases.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5480	In stock
100 mg		Get quote

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生物&药学活性

ORY-1001 dihydrochloride (RG-6016, Ladademstat) is a highly potent, selective inhibitor of lysine-specific demethylase KDM1A (LSD1) with IC50 of 18 nM, displays high selectivity for KDM1A over other FAD-containing monoamine oxidases.
ORY-1001 exhibits low nanomolar cellular activity (EC50 < 1 nM) in the THP1 differentiation assay and induces the CD11b marker within 6 hr of treatment in FACS based differentiation assay in THP1 cell line.
ORY-1001 induces H3K4me2 accumulation on KDM1A target genes, blast differentiation, and reduction of leukemic stem cell capacity in AML.
ORY-1001 exhibits potent synergy with standard-of-care drugs and selective epigenetic inhibitors, reduces growth of AML xenograft models.

物理化学性质&存储条件

分子量	303.271
分子式	C15H24Cl2N2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1r,4R)-N1-((1R,2S)-2-phenylcyclopropyl)cyclohexane-1,4-diamine dihydrochloride

参考文献

1. Maes T, et al. Cancer Cell. 2018 Mar 12;33(3):495-511.e12.

ORY-1001 dihydrochloride (Ladademstat dihydrochloride, RG-6016 dihydrochloride, ORY1001 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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ORY-1001 dihydrochloride (Ladademstat dihydrochloride, RG-6016 dihydrochloride, ORY1001 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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