IOX1 |CAS:5852-78-8 Probechem Biochemicals

Chemical Structure : IOX1

CAS No.: 5852-78-8

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IOX1 (IOX 1;IOX-1)

货号: PC-42967Not For Human Use, Lab Use Only.

IOX1 is a potent, broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases, with IC50 of <1 uM gainst the KDM3, KDM4 and KDM6, 5-25 uM against the KDM5 and KDM2/7.

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25 mg	￥1280	In stock
50 mg	￥2180	In stock
100 mg	￥3480	In stock
500 mg		Get quote
1 g		Get quote

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生物&药学活性

IOX1 is a potent, broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases, with IC50 of <1 uM gainst the KDM3, KDM4 and KDM6, 5-25 uM against the KDM5 and KDM2/7.
IOX1 is less potent against BBOX1 (IC50=196 uM); chelates to Fe(II) in the active site of 2OG oxygenases.
IOX1 suppresses the proliferation and migration of vascular smooth muscle cells induced by angiotensin II.

物理化学性质&存储条件

分子量	189.1675
分子式	C10H7NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 24 mg/mL
Chemical Name/SMILES	5-Quinolinecarboxylic acid, 8-hydroxy-

参考文献

1. Schiller R, et al. ChemMedChem. 2014 Mar;9(3):566-71.

2. Hu Q, et al. Int J Mol Med. 2016 Jan;37(1):189-96.

3. Mettananda S, et al. Haematologica. 2017 Mar;102(3):e80-e84.

4. Hopkinson RJ, et al. Chem Sci. 2013 Aug 1;4(8):3110-3117.

IOX1 (IOX 1;IOX-1)

生物&药学活性

物理化学性质&存储条件

参考文献

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IOX1 (IOX 1;IOX-1)

生物&药学活性

物理化学性质&存储条件

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