| Cat. No. |
Product Name |
Information |
| PC-27692 |
CRT0044876
APE1 inhibitor
|
CRT0044876 is a potent, specific apurinic/apyrimidinic endonuclease 1 (APE1, also termed HAP1 and Ref-1) inhibitor with IC50 of 3.06 uM, inhibits base excision repair. |
| PC-27690 |
MAD2L2 inhibitor C#3
MAD2L2 inhibitor
|
MAD2L2 inhibitor C#3 (ZINC25496030) is a small-molecule inhibitor of DNA polymerase Pol ζ (zeta) regulatory subunit MAD2L2 (Rev7), disrupts the MAD2L2-Rev1 interaction, potentially causes mutagenic translesion synthesis (TLS) inhibition, sensitizes lung cancer cell lines to cisplatin. |
| PC-27097 |
SU0617
SMUG1 inhibitor
|
SU0617 is a specific small molecule inhibitor of DNA repair enzyme SMUG1 with IC50 of 1.5 uM. |
| PC-26604 |
NP1867
PMS2 inhibitor
|
NP1867 (NP-1867) is a potent, first-in-class small molecule DNA mismatch repair (MMR) pathway modulator targeting PMS2 (PMS1 Homolog 2) with SPR KD of 65 nM for PMS2-N-terminal ATPase domain, IC50 of 22 nM in NanoBRET assays, blocks PMS2-NTD ATP binding site and inhibits DNA MMR. |
| PC-25978 |
Thymine DNA glycosylase inhibitor C-271
TDG inhibitor
|
C-271 is a first-in-class, specific small-molecule inhibitor of Thymine DNA glycosylase (TDG), inhibits TDG's glycosylase activity with similar efficacy across different substrates with IC50 of 0.16-0.25 uM, covalently targets TDG at C276. |
| PC-25188 |
TREX1-IN-1
TREX1 inhibitor
|
TREX1-IN-1 is a potent, effective inhibitor of cytosolic DNA exonuclease TREX1 (three-prime repair exonuclease 1) with IC50 of <0.1 uM for human TREX1. |
| PC-24665 |
GSK4418959
WRN inhibitor
|
GSK4418959 (IDE275) is a potent, non-covalent, reversible Werner helicase (WRN) inhibitor, binds to WRN in an allosteric pocket and inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. |
| PC-24067 |
SAR-24
PCNA inhibitor
|
SAR-24 (PCNA-I1S) is a small molecule inhibitor of proliferating cell nuclear antigen (PCNA), significantly affects chromatin-associated PCNA in tumor cells, effectively decreasing its levels and thereby inhibiting cancer cell proliferation. |
| PC-24057 |
KWR137
WRN inhibitor
|
KWR137 is a novel potent inhibitor of Werner protein WRN with IC50 of 8 nM (WRN ATPase). |
| PC-24056 |
KWR095
WRN inhibitor
|
KWR095 is a novel potent inhibitor of Werner protein WRN with IC50 of 32 nM (WRN ATPase). |
| PC-23997 |
SU0547
SMUG1 activator
|
SU0547 is a specific small-molecule activator of DNA repair enzyme SMUG1 (Single-Strand-Selective Monofunctional Uraci-DNA Glycosylase 1) with AC50 of 4.3 uM, activates SMUG1 by more than 40-fold in vitro. |
| PC-23727 |
MU147
MRE11 inhibitor
|
MU147 is a specific small molecule inhibitor of MRE11 nuclease with IC50 of 25.3 uM, inhibits MRE11-RAD50-NBS1 (MRN)-dependent homologous recombination. |
