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Request The Product List ofDNA Repair Protein DNA Repair Protein

Cat. No.	Product Name	Information
PC-22201	NUDT5/NUDT14 inhibitor 9 NUDT5/NUDT14 inhibitor	NUDT5/NUDT14 inhibitor 9 is a potent dual cell-active NUDT5/NUDT14 inhibitor with SPR KD of 400 nM for purified human NUDT14 protein.
PC-22121	VVD-133214 WRN inhibitor	VVD-133214 (VVD214, RO7589831) is a potent, selective, covalent allosteric inhibitor of WRN helicase, covalently engages cysteine 727 of WRN in a nucleotide cooperative manner and inhibits ATP hydrolysis and helicase activity.
PC-21907	Hycanthone APE1 inhibitor	Hycanthone is a thioxanthenone DNA intercalator, inhibits RNA synthesis as well as the DNA topoisomerases I and II, inhibits apurinic endonuclease 1 (APE1) incision of depurinated plasmid DNA with IC50 of 80 nM.
PC-21245	KY386 DHX33 inhibitor	KY386 is a potent, selective inhibitor of RNA helicase DHX33 with IC50 of 19 nM.
PC-21006	H3B-968 WRN helicase inhibitor	H3B-968 is a potent, selective and covalent inhibitor of Werner syndrome protein (WRN) helicase activity with IC50 of 41 and 13 nM in ADP-Glo assay DNA unwinding assay, respectively.
PC-21005	H3B-960 WRN helicase inhibitor	H3B-960 is a potent, selective and covalent inhibitor of Werner syndrome protein (WRN) helicase activity with IC50 of 60 nM.
PC-20997	AOH1996 PCNA inhibitor	AOH1996 (AOH-1996) is a small molecule, orally active inhibitor of cancer-associated isoform of proliferating cell nuclear antigen (caPCNA), exerts potent, selective anticancer effects.
PC-20677	Werner syndrome RecQ helicase-IN-4 WRN inhibitor	Werner syndrome RecQ helicase-IN-4 is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor with IC50 of 60 nM for WRN ATPase.
PC-20676	Werner syndrome RecQ helicase-IN-3 WRN inhibitor	Werner syndrome RecQ helicase-IN-3 is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor with IC50 of 60 nM for WRN ATPase.
PC-20675	Werner syndrome RecQ helicase-IN-2 WRN inhibitor	Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor with IC50 of 100 nM for WRN ATPase.
PC-20674	HRO761 WRN inhibitor	HRO761 (HRO-761) is the first potent and selective, allosteric inhibitor of RecQ DNA helicase WRN with IC50 of 50 nM, shows potent and selective anti-tumor activity in cancers with microsatellite instability.
PC-49111	SU0448 MTH1 activator	SU0448 is a specific, cell-permeable small molecule activator of the DNA repair enzyme Human MutT Homolog 1 (MTH1) with AC50 value of 5.5 uM, inhibits cell viability of HCC1806 cells with IC50 of 36.1 uM.

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