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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Repair Protein -FORX-864
FORX-864

Chemical Structure : FORX-864

CAS No.:

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FORX-864 (FORX864)

货号: PC-28497Not For Human Use, Lab Use Only.

FORX-864 is a potent, selective, covalent RAD52 inhibitor with IC50 of 5 nM in FP assays, inhibits RAD52-dependent single-strand annealing with IC50 of 0.96 uM in U2OS SA-GFP SSA reporter assay.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

FORX-864 is a potent, selective, covalent RAD52 inhibitor with IC50 of 5 nM in FP assays, inhibits RAD52-dependent single-strand annealing with IC50 of 0.96 uM in U2OS SA-GFP SSA reporter assay.

物理化学性质&存储条件

分子量 716.80
分子式 C36H33FN4O7S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(4-acrylamido-2-fluorobenzyl)-2-(3-(2-((2-(3-(5-carboxy-4-methylthiazol-2-yl)phenoxy)ethyl)(methyl)amino)ethoxy)phenyl)thiazole-5-carboxylic acid

参考文献

1. Bocquet N, et al. J Am Chem Soc. 2026 Oct 8. doi: 10.1021/jacs.6c16278.

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