CRT0044876 | APE1 inhibitor | Probechem Biochemicals

Chemical Structure : CRT0044876

CAS No.: 6960-45-8

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CRT0044876 (CRT-0044876)

货号: PC-27692Not For Human Use, Lab Use Only.

CRT0044876 is a potent, specific apurinic/apyrimidinic endonuclease 1 (APE1, also termed HAP1 and Ref-1) inhibitor with IC50 of 3.06 uM, inhibits base excision repair.

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生物&药学活性

CRT0044876 is a potent, specific apurinic/apyrimidinic endonuclease 1 (APE1, also termed HAP1 and Ref-1) inhibitor with IC50 of 3.06 uM, inhibits base excision repair.
CRT0044876 not only inhibits AP site cleavage catalyzed by purified APE1, but also cleavage directed by APE1 in a HeLa whole cell extract.
CRT0044876 is an inhibitor of the exonuclease III family of AP endonucleases, inhibits both the exonuclease and AP endonuclease activities of exonuclease III, but shows no inhibitory activity towards endonuclease IV.
CRT0044876 inhibits the 3'-phosphoglycolate diesterase activity of APE1 with an IC50 of 5 uM.

物理化学性质&存储条件

分子量	206.16
分子式	C9H6N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-Nitro-1H-indole-2-carboxylic acid

参考文献

1. Madhusudan S, et al. Nucleic Acids Res. 2005 Aug 19;33(15):4711-24.

2. Pidugu LS, et al. PLoS One. 2023 Jan 18;18(1):e0280526.

3. Koll TT, et al. Mol Cancer Ther. 2008 Jul;7(7):1985-92.

CRT0044876 (CRT-0044876)

生物&药学活性

物理化学性质&存储条件

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CRT0044876 (CRT-0044876)

生物&药学活性

物理化学性质&存储条件

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