| Cat. No. |
Product Name |
Information |
| PC-35174 |
MLAF50
REV1 UBM2 inhibitor
|
MLAF50 is the first small-molecule inhibitor of the REV1 UBM2-Ubiquitin interaction, directly binds to REV1 UBM2 with Kd of 37 uM in SPR assays. |
| PC-42991 |
ML216
BLM helicase inhibitor
|
ML216 (CID49852229) is a potent, selective inhibitor of DNA unwinding activity of BLM (Bloom's syndrome protein) with IC50 of 2.98 and 0.97 uM for full length BLM and BLM636-1298, respectively. |
| PC-63192 |
IACS-4619
MTH1 inhibitor
|
IACS-4619 is a potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM. |
| PC-62970 |
IBR2
RAD51 inhibitor
|
IBR2 is a novel small molecule RAD51 inhibitor that specifically binds to RAD51 and disrupts the BRC repeats of BRCA2/RAD51 interaction with IC50 of 0.11 uM. |
| PC-62839 |
RAD51-IN-17
RAD51 inhibitor
|
RAD51-IN-17 is a quinazolinone derivative that inhibts homologous recombinase RAD51, effectively inhibits both RAD51 foci formation in response to DNA damage, and proliferation of TNBC cell lines. |
| PC-62706 |
Karonudib
MTH1 inhibitor
|
Karonudib (TH1579) is an analogue of TH588, a potent, selective MTH1 inhibitor with good oral availability and demonstrates excellent pharmacokinetic and anti-cancer properties in vivo.. |
| PC-62705 |
IACS-4759
MTH1 inhibitor
|
IACS-4759 is a potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM. |
| PC-62517 |
TH5427
NUDT5 inhibitor
|
TH 5427 (TH5427) is a potent, small molecule NUDT5 (NUDIX hydrolase type 5) inhibitor with IC50 of 29 nM, 690-fold selectivity for NUDT5 over MTH1 (NUDT1) in vitro. |
| PC-62268 |
YU 238259
Homology-dependent DNA repair inhibitor
|
YU 238259 is a novel DNA double-strand break repair inhibitor that exhibits potent synthetic lethality in the setting of DNA damage response and DNA repair defects. |
| PC-61929 |
D-G23
RAD52 inhibitor
|
D-G23 is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5.8 uM, binds to RAD52 with Kd of 34 uM and inhibits D-loop formation with IC50 of 7.2 uM in vitro. |
| PC-61928 |
D-I03
RAD52 inhibitor
|
D-I03 (D-103) is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5 uM, binds to RAD52 with Kd of 25.8 uM and inhibits D-loop formation with IC50 of 8 uM in vitro. |
| PC-61927 |
(E)-Mirin
|
Mirin is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits MRN-mediated ATM activation (inhibition of H2AX phosphorylation) with IC50 of 66 uM. |
