A83B4C63 | PNKP inhibitor | Probechem Biochemicals

Chemical Structure : A83B4C63

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A83B4C63 (PNKP inhibitor)

货号: PC-73255Not For Human Use, Lab Use Only.

A83B4C63 is a potent small molecule DNA repair protein, polynucleotide kinase 3′-phosphatase (PNKP) inhibitor with Kd of 80 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

A83B4C63 is a potent small molecule DNA repair protein, polynucleotide kinase 3'-phosphatase (PNKP) inhibitor with Kd of 80 nM.
A83B4C63 is a nano-encapsulated potent, but poorly water-soluble lead PNKP inhibitor with therapeutic potential for PTEN-deficient CRC.
Nano-carriers of A83B4C63 effectively inhibited the growth of HCT116/PTEN-/- xenografts in NIH-III nude mice following intravenous (IV) administration, but not that of wild-type HCT116/PTEN+/+ xenografts.
A83B4C63 encapsulated in NPs (NP/A83) based on mPEO-b-PBCL or solubilized with CE/A83, sensitized colorectal cancer cells to DNA damaging therapeutics in human HCT116 colorectal cancer (CRC) models.

物理化学性质&存储条件

分子量	564.598
分子式	C32H28N4O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(hydroxy(2-methoxyphenyl)methyl)-6-(naphthalen-1-ylmethyl)-1-((4-nitrophenyl)amino)-1,2,4a,7a-tetrahydro-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione

参考文献

1. Shire Z, et al. Mol Pharm. 2018 Jun 4;15(6):2316-2326.

2. Sadat SMA, et al. J Control Release. 2021 Jun 10;334:335-352.

3. Sadat SMA, et al. Front Oncol. 2021 Dec 23;11:772920.