| Cat. No. |
Product Name |
Information |
| PC-72501 |
JH-RE-06
REV1-REV7 inhibitor
|
JH-RE-06 is a potent REV1-REV7 interface inhibitor (IC50=0.78 uM, Kd=0.42 uM) that disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ, induces REV1 dimerization and blocks POLζ recruitment. |
| PC-72496 |
TH8321
NUDT15 inhibitor
|
TH8321 (TH-8321) is a potent, selective NUDT15 inhibitor with IC50 of 35 nM. |
| PC-72026 |
AZ13792138
NUDT1 inhibitor
|
AZ13792138 is a highly potent, selective inhibitor of MTH1 (NUDT1) with Kd/IC50 of 0.4/0.5 nM. |
| PC-72025 |
SU0383
OGG1-MTH1 inhibitor
|
SU0383 (SU 0383) is a potent, dual inhibitor of repair enzyme OGG1 and NUDT1 (MTH1) with IC50 of 34 nM and 490 nM, respectively. |
| PC-38226 |
TH1760
NUDT15 inhibitor
|
TH1760 (TH 1760) is a first-in-class, potent, selective, cell-active NUDT15 inhibitor with IC50 of 25 nM. |
| PC-35806 |
TH5487
OGG1 inhibitor
|
TH5487 (TH-5487, TH 5487) is a potent, selective, active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 342 nM, prevents OGG1 from binding to its DNA substrate. |
| PC-35563 |
APX2014
Ref-1/APE1 inhibitor
|
APX2014 (APX-2014) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.2 uM for redox EMSA inhibition. |
| PC-35301 |
AOH1160
PCNA inhibitor
|
AOH1160 (AOH-1160) is a potent, first-in-class, orally available small molecule inhibitor of Proliferating cell nuclear antigen (PCNA). |
| PC-35266 |
A12B4C3
hPNKP inhibitor
|
A12B4C3 is a potent, specific human polynucleotide kinase/phosphatase (hPNKP) inhibitor, inhibits hPNKP phosphatase activity with IC50 of 60 nM. |
| PC-35174 |
MLAF50
REV1 UBM2 inhibitor
|
MLAF50 is the first small-molecule inhibitor of the REV1 UBM2-Ubiquitin interaction, directly binds to REV1 UBM2 with Kd of 37 uM in SPR assays. |
| PC-42991 |
ML216
BLM helicase inhibitor
|
ML216 (CID49852229) is a potent, selective inhibitor of DNA unwinding activity of BLM (Bloom's syndrome protein) with IC50 of 2.98 and 0.97 uM for full length BLM and BLM636-1298, respectively. |
| PC-63192 |
IACS-4619
MTH1 inhibitor
|
IACS-4619 is a potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM. |
