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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Repair Protein -MLAF50
MLAF50

Chemical Structure : MLAF50

CAS No.: 1417653-96-3

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MLAF50 (MLAF 50)

货号: PC-35174Not For Human Use, Lab Use Only.

MLAF50 is the first small-molecule inhibitor of the REV1 UBM2-Ubiquitin interaction, directly binds to REV1 UBM2 with Kd of 37 uM in SPR assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MLAF50 is the first small-molecule inhibitor of the REV1 UBM2-Ubiquitin interaction, directly binds to REV1 UBM2 with Kd of 37 uM in SPR assays.
    MLAF50 inhibits chromatin localization of REV1 in cells after damaging DNA.
    MLAF50 binds to the same residues of REV1 UBM2 that interact with ubiquitin, indicating that MLAF50 can compete with the REV1 UBM2-ubiquitin interaction orthosterically.

    物理化学性质&存储条件

    分子量 510.066
    分子式 C15H12I2O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(3-(4-hydroxyphenoxy)-2,4-diiodophenyl)propanoic acid

    参考文献

    1. Vanarotti M, et al. J Mol Biol. 2018 Jun 2. pii: S0022-2836(18)30553-9.

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