IACS-4619 (IACS4619)

首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Repair Protein -IACS-4619

Chemical Structure : IACS-4619

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货号: PC-63192Not For Human Use, Lab Use Only.

IACS-4619 is a potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IACS-4619 is a potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM.
IACS-4619 shows no off-target kinase activity in a panel of 97 kinases.
IACS-4619 exhibits excellent cell permeability and good metabolic stability in microsomes.
IACS-4619 is an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology.

物理化学性质&存储条件

分子量	195.266
分子式	C10H17N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-methyl-4-(neopentyloxy)pyrimidin-2-amine

参考文献

1. Petrocchi A, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1503-7.

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