TH5487 | OGG1 inhibitor | Probechem Biochemicals

Chemical Structure : TH5487

CAS No.: 2304947-71-3

加入收藏

TH5487 (TH-5487)

货号: PC-35806Not For Human Use, Lab Use Only.

TH5487 (TH-5487, TH 5487) is a potent, selective, active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 342 nM, prevents OGG1 from binding to its DNA substrate.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2780	In stock
50 mg	￥4780	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

TH5487 (TH-5487, TH 5487) is a potent, selective, active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 342 nM, prevents OGG1 from binding to its DNA substrate.
TH5487 does not affect the activity of other DNA glycosylases or various Nudix hydrolases and diphosphatase, also not intercalate DNA.
TH5487 decreases binding of OGG1 to promoters in chromatin, engages OGG1 in cells, inhibits DNA repair, and alters OGG1 chromatin dynamics.
TH5487 specifically inhibit OGG1-dependent proinflammatory gene expression, decreases CXCL1 expression by >50% in wild-type but not in OGG1-knockout cells at 5 uM, inhibits TNFα-induced expression of TNF in hSAECs.
TH5487 suppresses proinflammatory gene expression and lung inflammation in mice (30 mg/kg, i.p.).

物理化学性质&存储条件

分子量	541.187
分子式	C19H18BrIN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-bromo-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-(4-iodophenyl)piperidine-1-carboxamide

参考文献

1. Visnes T, et al. Science. 2018 Nov 16;362(6416):834-839.

TH5487 (TH-5487)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

TH5487 (TH-5487)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.