| Cat. No. |
Product Name |
Information |
| PC-62970 |
IBR2
RAD51 inhibitor
|
IBR2 is a novel small molecule RAD51 inhibitor that specifically binds to RAD51 and disrupts the BRC repeats of BRCA2/RAD51 interaction with IC50 of 0.11 uM. |
| PC-62839 |
RAD51-IN-17
RAD51 inhibitor
|
RAD51-IN-17 is a quinazolinone derivative that inhibts homologous recombinase RAD51, effectively inhibits both RAD51 foci formation in response to DNA damage, and proliferation of TNBC cell lines. |
| PC-62706 |
Karonudib
MTH1 inhibitor
|
Karonudib (TH1579) is an analogue of TH588, a potent, selective MTH1 inhibitor with good oral availability and demonstrates excellent pharmacokinetic and anti-cancer properties in vivo.. |
| PC-62705 |
IACS-4759
MTH1 inhibitor
|
IACS-4759 is a potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM. |
| PC-62517 |
TH5427
NUDT5 inhibitor
|
TH5427 (TH-5427) is a potent, small molecule NUDT5 (NUDIX hydrolase type 5) inhibitor with IC50 of 29 nM, 690-fold selectivity for NUDT5 over MTH1 (NUDT1) in vitro. |
| PC-62268 |
YU 238259
Homology-dependent DNA repair inhibitor
|
YU 238259 is a novel DNA double-strand break repair inhibitor that exhibits potent synthetic lethality in the setting of DNA damage response and DNA repair defects. |
| PC-61929 |
D-G23
RAD52 inhibitor
|
D-G23 is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5.8 uM, binds to RAD52 with Kd of 34 uM and inhibits D-loop formation with IC50 of 7.2 uM in vitro. |
| PC-61928 |
D-I03
RAD52 inhibitor
|
D-I03 (D-103) is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5 uM, binds to RAD52 with Kd of 25.8 uM and inhibits D-loop formation with IC50 of 8 uM in vitro. |
| PC-61927 |
Mirin
MRE11 inhibitor
|
Mirin is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits MRN-mediated ATM activation (inhibition of H2AX phosphorylation) with IC50 of 66 uM. |
| PC-61926 |
PFM01
MRE11 inhibitor
|
PFM01 (SML1735) is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM. |
| PC-61925 |
PFM39
MRE11 inhibitor
|
PFM39 (SML1839) is a small molecule that specifically inhibits exonuclease activity of MRE11, binds in the active site similar to mirin, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, inhibits HR without significantly increasing NHEJ. |
| PC-61924 |
6-Hydroxy-DOPA
RAD52 inhibitor
|
6-Hydroxy-DOPA (6-OH-DOPA) is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM. |
