BAY-707 |CAS:2109805-96-9 Probechem Biochemicals

Chemical Structure : BAY-707

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BAY-707 (BAY 707;BAY707)

货号: PC-61067Not For Human Use, Lab Use Only.

BAY-707 is a highly potent, selective and substrate-competitive inhibitor of MTH1 (NUDT1) with IC50 of 2.3 nM.

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生物&药学活性

BAY-707 (BAY707) is a highly potent, selective and substrate-competitive inhibitor of MTH1 (NUDT1) with IC50 of 2.3 nM.
BAY-707 demonstrates high selectivity in an in-house kinase panel, and shows an overall favorable physicochemical profile and in vitro pharmacokinetic properties with high metabolic stability.
BAY-707 demonstrates a superior cellular target engagement with an EC50 of 7.6 nM compared with TH588, increases the cellular thermal stabilization of MTH1 with no effect on the expression of MTH2, OGG1, and MUTYH.
BAY-707 shows a clear lack of in vitro or in vivo anticancer efficacy either in mono- or in combination therapies in vivo.

物理化学性质&存储条件

分子量	288.351
分子式	C15H20N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-ethyl-4-(3-methylmorpholino)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide

参考文献

1. Ellermann M, et al. ACS Chem Biol. 2017 Aug 18;12(8):1986-1992.

BAY-707 (BAY 707;BAY707)

生物&药学活性

物理化学性质&存储条件

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BAY-707 (BAY 707;BAY707)

生物&药学活性

物理化学性质&存储条件

参考文献

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