NSC 19630 |CAS:72835-26-8 Probechem Biochemicals

Chemical Structure : NSC 19630

CAS No.: 72835-26-8

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NSC 19630 (MIRA-1)

货号: PC-61921Not For Human Use, Lab Use Only.

NSC 19630 (MIRA-1) is a potent, selective Werner syndrome helicase (WRN helicase) with IC50 of 20 uM.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1880	In stock
100 mg	￥2980	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

NSC 19630 (MIRA-1) is a potent, selective Werner syndrome helicase (WRN helicase) with IC50 of 20 uM.
NSC 19630 (MIRA-1) shows selecitvity over human RecQ helicases (RECQ1 and BLM), Fanconi anemia group J (FANCJ) helicases and three Escherichia coli helicases (RecQ, UvrD, and DnaB).
NSC 19630 (MIRA-1) dramatically impaires growth and proliferation, induces apoptosis in a WRN-dependent manner, and resultes in elevated γ-H2AX and PCNA foci in human cells.
NSC 19630 (MIRA-1) delays S-phase progression and induces DNA damage;.
NSC 19630 (MIRA-1) is a mutant p53 reactivator that induces mutant p53-dependent cell death in different human tumor cells carrying tetracycline-regulated mutant p53.

物理化学性质&存储条件

分子量	183.2
分子式	C8H9NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[(1-oxopropoxy)methyl]-1H-pyrrole-2,5-dione

参考文献

1. Aggarwal M, et al. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1525-30.

2. Saha MN, et al. Br J Cancer. 2014 Apr 29;110(9):2224-31.

3. Bykov VJ, et al. J Biol Chem. 2005 Aug 26;280(34):30384-91.

NSC 19630 (MIRA-1)

生物&药学活性

物理化学性质&存储条件

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NSC 19630 (MIRA-1)

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