| Cat. No. |
Product Name |
Information |
| PC-43226 |
TH-588
MTH1 inhibitor
|
TH-588 is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 5 nM. |
| PC-45105 |
TH-287 hydrochloride
MTH1 inhibitor
|
TH-287 hydrochloride is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 0.8 nM. |
| PC-45104 |
TH-287
MTH1 inhibitor
|
TH-287 is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 0.8 nM. |
| PC-26135 |
ART5537
EXO1 inhibitor
|
ART5537 (ART-5537) is highly potent and selective inhibitor of Exonuclease 1 (EXO1) with IC50 of 3.4 nM, inhibits homologous recombination (HR) with EC50 of 7.2 nM in HR reporter assays. |
| PC-26081 |
MU876
MUS81 inhibitor
|
MU876 is a specific small molecule inhibitor of endonuclease MUS81 with IC50 of 0.52 uM in biochemical nuclease assay, inhibits MUS81-mediated DNA repair pathways in cells. |
| PC-26080 |
MU262
MUS81 inhibitor
|
MU262 is a specific small molecule inhibitor of endonuclease MUS81 with IC50 of 0.87 uM in biochemical nuclease assay, inhibits MUS81-mediated DNA repair pathways in cells. |
| PC-25461 |
WRN degrader 14c
WRN degrader
|
WRN degrader 14c is a potent, selective degrader of Werner syndrome helicase (WRN) with DC50 of 1.7 uM in MSI-H HCT116 cells, covalently conjugates to C727 within the WRN helicase domain, forming an adamantane-tagged adduct that initiates sustained proteasomal degradation. |
| PC-25188 |
TREX1-IN-1
TREX1 inhibitor
|
TREX1-IN-1 is a potent, small molecule inhibitor of three-prime repair exonuclease 1 (TREX1) enzyme with IC50 of <0.1 uM. |
| PC-24739 |
WRN inhibitor 40
WRN inhibitor
|
WRN inhibitor 40 is a potent, selective and covalent WRN helicase inhibitor with IC50 of 3.7 nM in WRN unwinding assay, targets WRN Cys727. |
| PC-24066 |
ATX-101
PCNA inhibitor
|
ATX-101 is an APIM-containing cell-penetrating peptide targeting PCNA, impairs the APIM-PCNA interaction. |
| PC-23728 |
PFM03
MRE11 inhibitor
|
PFM03 is a specific MRE11 endonuclease inhibitor, affects DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ). |
| PC-22774 |
HDGFRP2 PWWP domain inhibitor BBP
HDGFRP2 PWWP inhibitor
|
BBP is a small molecule inhibitor of the hepatoma-derived growth factor-related protein 2 (HDGFRP2) PWWP domain, dually targets both HDGFRP2 and PSIP1 PWWP domains, engage with the aromatic cage of the HDGFRP2 PWWP domain. |
