IACS-4759 |CAS:1884209-99-7 Probechem Biochemicals

Chemical Structure : IACS-4759

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IACS-4759 (IACS4759)

货号: PC-62705Not For Human Use, Lab Use Only.

IACS-4759 is a potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM.

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生物&药学活性

IACS-4759 is a potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM.
IACS-4759 shows no off-target kinase activity in a panel of 97 kinases.
IACS-4759 exhibits excellent cell permeability and good metabolic stability in microsomes.
IACS-4759 is an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology.

物理化学性质&存储条件

分子量	211.265
分子式	C10H17N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((2-amino-5-methylpyrimidin-4-yl)oxy)-2,2-dimethylpropan-1-ol

参考文献

1. Petrocchi A, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1503-7.

IACS-4759 (IACS4759)

生物&药学活性

物理化学性质&存储条件

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IACS-4759 (IACS4759)

生物&药学活性

物理化学性质&存储条件

参考文献

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