TH5427 | NUDT5 inhibitor | Probechem Biochemicals

Chemical Structure : TH5427

CAS No.: 2253744-56-6

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TH5427 (TH-5427, TH 5427)

货号: PC-62517Not For Human Use, Lab Use Only.

TH 5427 (TH5427) is a potent, small molecule NUDT5 (NUDIX hydrolase type 5) inhibitor with IC50 of 29 nM, 690-fold selectivity for NUDT5 over MTH1 (NUDT1) in vitro.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

TH5427 (TH5427) is a potent, small molecule NUDT5 (NUDIX hydrolase type 5) inhibitor with IC50 of 29 nM, 690-fold selectivity for NUDT5 over MTH1 (NUDT1) in vitro.
TH5427 shows little to no effect on NUDT9, dCTPase, NUDT12 and NUDT14.
TH5427 inhibits progestin-dependent nuclear ATP synthesis, subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells.
TH5427 is a potent NUDT5 inhibitor that blocks hormone-dependent gene expression in breast cancer cells.

物理化学性质&存储条件

分子量	491.333
分子式	C20H20Cl2N8O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-((5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl)methyl)-1,3-dimethyl-8-(piperazin-1-yl)-3,7-dihydro-1H-purine-2,6-dione

参考文献

1. Page BDG, et al. Nat Commun. 2018 Jan 17;9(1):250.

TH5427 (TH-5427, TH 5427)

生物&药学活性

物理化学性质&存储条件

参考文献

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TH5427 (TH-5427, TH 5427)

生物&药学活性

物理化学性质&存储条件

参考文献

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