D-G23 |CAS:1225141-73-0 Probechem Biochemicals

Chemical Structure : D-G23

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D-G23 (RAD52 inhibitor)

货号: PC-61929Not For Human Use, Lab Use Only.

D-G23 is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5.8 uM, binds to RAD52 with Kd of 34 uM and inhibits D-loop formation with IC50 of 7.2 uM in vitro.

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生物&药学活性

D-G23 is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5.8 uM, binds to RAD52 with Kd of 34 uM and inhibits D-loop formation with IC50 of 7.2 uM in vitro.
D-G23 suppresses growth of BRCA1- and BRCA2-deficient cells (at >10 uM concentration).

物理化学性质&存储条件

分子量	354.41
分子式	C19H22N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((2-((2,5-dimethoxyphenyl)amino)quinazolin-4-yl)amino)propan-1-ol

参考文献

1. Huang F, et al. Nucleic Acids Res. 2016 May 19;44(9):4189-99.

2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.

D-G23 (RAD52 inhibitor)

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物理化学性质&存储条件

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D-G23 (RAD52 inhibitor)

生物&药学活性

物理化学性质&存储条件

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