D-I03 |CAS:688342-78-1 Probechem Biochemicals

Chemical Structure : D-I03

CAS No.: 688342-78-1

加入收藏

D-I03 (D103)

货号: PC-61928Not For Human Use, Lab Use Only.

D-I03 (D-103) is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5 uM, binds to RAD52 with Kd of 25.8 uM and inhibits D-loop formation with IC50 of 8 uM in vitro.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1780	In stock
25 mg	￥2980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

D-I03 (D-103) is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5 uM, binds to RAD52 with Kd of 25.8 uM and inhibits D-loop formation with IC50 of 8 uM in vitro。
D-I03 suppresses growth of BRCA1- and BRCA2-deficient cells (at 2.5 uM concentration) and inhibits RAD52-mediated SSA in human U2OS cells。
D-I03 selective toward SSA over homologous recombination (HR).

物理化学性质&存储条件

分子量	428.643
分子式	C23H36N6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-(diethylamino)ethyl)-3-(2-(4-ethylpiperazin-1-yl)-4-methylquinolin-6-yl)thiourea

参考文献

1. Huang F, et al. Nucleic Acids Res. 2016 May 19;44(9):4189-99.

2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.

D-I03 (D103)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

D-I03 (D103)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.