Mirin |CAS:1198097-97-0 Probechem Biochemicals

Chemical Structure : Mirin

CAS No.: 1198097-97-0

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Mirin ((Z)-Mirin)

货号: PC-45763Not For Human Use, Lab Use Only.

(Z)-Mirin is a small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity.

规格	价格	库存
25 mg	￥1380	In stock
50 mg	￥2280	In stock
100 mg	￥3980	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

(Z)-Mirin is a small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity.
(Z)-Mirin prevents MRN-dependent activation of ATM (IC50=12 uM) without affecting ATM protein kinase activity.
(Z)-Mirin inhibits Mre11 nuclease activity at 100 uM, does not inhibit ExoIII nuclease activity.
(Z)-Mirin inhibits the G2 checkpoint, and blocks homology-directed repair (HDR) in mammalian cells.

物理化学性质&存储条件

分子量	220.2477
分子式	C10H8N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	4(5H)-Thiazolone, 2-amino-5-[(4-hydroxyphenyl)methylene]-, (5Z)-

参考文献

1. Dupré A, et al. Nat Chem Biol. 2008 Feb;4(2):119-25.

2. Lee JH, et al. J Biol Chem. 2013 May 3;288(18):12840-51.

3. Rozier L, et al. Mol Cell. 2013 Mar 28;49(6):1097-107.

Mirin ((Z)-Mirin)

生物&药学活性

物理化学性质&存储条件

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Mirin ((Z)-Mirin)

生物&药学活性

物理化学性质&存储条件

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