NSC 617145 |CAS:203115-63-3 Probechem Biochemicals

Chemical Structure : NSC 617145

CAS No.: 203115-63-3

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NSC 617145 (NSC617145)

货号: PC-61920Not For Human Use, Lab Use Only.

NSC 617145 is a novel small-molecule, selective inhibitor of WRN helicase with IC50 of 230 nM.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥1880	In stock
50 mg	￥2780	In stock
100 mg		Get quote

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生物&药学活性

NSC 617145 is a novel small-molecule, selective inhibitor of WRN helicase with IC50 of 230 nM.
NSC 617145 shows no significant inhibition on BLM, FANCJ, ChlR1, RecQ, and UvrD.
NSC 617145 acts synergistically with very low concentrations of mitomycin C to inhibit proliferation in a WRN-dependent manner and induce DSB and chromosomal abnormalities in FA-D2(-/-) cells.

物理化学性质&存储条件

分子量	400.04
分子式	C13H10Cl4N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,1'-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-pyrrole-2,5-dione

参考文献

1. Aggarwal M, et al. Cancer Res. 2013 Sep 1;73(17):5497-507.

2. Aggarwal M, et al. Cell Cycle. 2013 Oct 15;12(20):3329-35.

3. Moles R, et al. J Hematol Oncol. 2016 Nov 9;9(1):121.

NSC 617145 (NSC617145)

生物&药学活性

物理化学性质&存储条件

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NSC 617145 (NSC617145)

生物&药学活性

物理化学性质&存储条件

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