6-Hydroxy-DOPA |CAS:21373-30-8 Probechem Biochemicals

Chemical Structure : 6-Hydroxy-DOPA

CAS No.: 21373-30-8

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6-Hydroxy-DOPA (6-OH-DOPA)

货号: PC-61924Not For Human Use, Lab Use Only.

6-Hydroxy-DOPA (6-OH-DOPA) is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM.

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5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

6-Hydroxy-DOPA (6-OH-DOPA) is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM.
6-Hydroxy-DOPA inhibits RAD52 foci formation in murine hematopoietic cells deficient in BRCA1, and kills BRCA-deficient cancer cells.
6-Hydroxy-DOPA also inhibits human apurinic/apyrimidinic endonuclease APE1 and enhances the cytotoxic and genotoxic potency of the alkylating agent methylmethane sulfonate.

物理化学性质&存储条件

分子量	213.189
分子式	C9H11NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Alanine, 3-(2,4,5-trihydroxyphenyl)- (7CI,8CI)

参考文献

1. Chandramouly G, et al. Chem Biol. 2015 Nov 19;22(11):1491-1504.

2. Simeonov A, et al. PLoS One. 2009 Jun 1;4(6):e5740.

3. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.

6-Hydroxy-DOPA (6-OH-DOPA)

生物&药学活性

物理化学性质&存储条件

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6-Hydroxy-DOPA (6-OH-DOPA)

生物&药学活性

物理化学性质&存储条件

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