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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Repair Protein -TH-588 hydrochloride
TH-588 hydrochloride

Chemical Structure : TH-588 hydrochloride

CAS No.: 1640282-30-9

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TH-588 hydrochloride (TH588 hydrochloride)

货号: PC-43227Not For Human Use, Lab Use Only.

TH-588 hydrochloride is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 5 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TH-588 hydrochloride is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 5 nM.
TH-588 hydrochloride shows no relevant inhibition for MTH2,NUDT5, NUDT12,NUDT14,NUDT16 and other proteinswith known nucleoside triphosphate pyrophosphatase activity.
TH-588 hydrochloride causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.

物理化学性质&存储条件

分子量 331.6281
分子式 C13H13Cl3N4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,4-Pyrimidinediamine, N4-cyclopropyl-6-(2,3-dichlorophenyl)-, hydrochloride (1:1)

参考文献

1. Gad H, et al. Nature. 2014 Apr 10;508(7495):215-21.

2. Wang M, et al. Sci Rep. 2017 Jan 11;7:40557.

3. Warpman Berglund U, et al. Ann Oncol. 2016 Dec;27(12):2275-2283.

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