ML216 | BLM helicase inhibitor | Probechem Biochemicals

Chemical Structure : ML216

CAS No.: 1430213-30-1

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ML216 (ML-216, CID49852229)

货号: PC-42991Not For Human Use, Lab Use Only.

ML216 (CID49852229) is a potent, selective inhibitor of DNA unwinding activity of BLM (Bloom's syndrome protein) with IC50 of 2.98 and 0.97 uM for full length BLM and BLM636-1298, respectively.

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10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

ML216 (CID49852229) is a potent, selective inhibitor of DNA unwinding activity of BLM (Bloom's syndrome protein) with IC50 of 2.98 and 0.97 uM for full length BLM and BLM636-1298, respectively.
ML216 weak inhibits WRN helicase (IC50=12.6 uM) and does not inhibit RecQ1, RecQ5 and UrvD (IC50>50 uM).
ML216 disrupts BLM’s binding to DNA, rather than being an inhibitor of ATP binding by BLM, the inhibition of ssDNA-dependent ATPase activity with Ki of 1.76 uM,.
ML216 shows cell-based activity and can induce sister chromatid exchanges, enhances the toxicity of aphidicolin, and exerts antiproliferative activity in cells expressing BLM.

物理化学性质&存储条件

分子量	383.3235
分子式	C15H9F4N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 1.71 mg/mL
Chemical Name/SMILES	Urea, N-[4-fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]-

参考文献

1. Nguyen GH, et al. Chem Biol. 2013 Jan 24;20(1):55-62.

2. Rosenthal AS, et al. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5660-6.

ML216 (ML-216, CID49852229)

生物&药学活性

物理化学性质&存储条件

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ML216 (ML-216, CID49852229)

生物&药学活性

物理化学性质&存储条件

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