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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Repair Protein -TH8321
TH8321

Chemical Structure : TH8321

CAS No.:

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TH8321 (TH-8321)

货号: PC-72496Not For Human Use, Lab Use Only.

TH8321 (TH-8321) is a potent, selective NUDT15 inhibitor with IC50 of 35 nM.

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5 mg ￥2480 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TH8321 (TH-8321) is a potent, selective NUDT15 inhibitor with IC50 of 35 nM.
TH8321 demonstrated satisfactory selectivity among a panel of related proteins, including NUDT22, NUDT18, NUDT12, NUDT9, NUDT5, NUDT2, MTH1, ITPase, dCTPase, and dUTPase.
TH8321 potently engaged and inhibited cellular NUDT15, TH8321 (5 uM) substantially potentiated the anti-HCMV efficacy of ganciclovir in HCMV infected MRC-5 cells, recapitulating the effect of NUDT15 knockdown.

物理化学性质&存储条件

分子量 355.46
分子式 C18H21N5OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-amino-9-cyclohexyl-8-(2-methoxyphenyl)-3,9-dihydro-6H-purine-6-thione

参考文献

1. Si Min Zhang, et al. Cell Chem Biol. 2021 Dec 16;28(12):1693-1702.e6.

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