APX2014 | Ref-1/APE1 inhibitor | Probechem Biochemicals

Chemical Structure : APX2014

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APX2014 (APX 2014, APX-2014)

货号: PC-35563Not For Human Use, Lab Use Only.

APX2014 (APX-2014) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.2 uM for redox EMSA inhibition.

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生物&药学活性

APX2014 (APX-2014) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.2 uM for redox EMSA inhibition.
APX2014 inhibits endothelial cell proliferation in HRECs and Rf/6a cells in vitro with GI50 of 0.11 and 5 uM, respectively.
APX2014 significantly inhibits endothelial tube formation in HRECs and Rf/6a cells in vitro, inhibits TNF-α mediated NF-κB signaling and proangiogenic target gene mRNA expression.
APX2014 inhibits choroidal sprouting at high nanomolar concentrations in ex vivo, blocks ocular angiogenesis in vitro and ex vivo.

物理化学性质&存储条件

分子量	329.352
分子式	C18H19NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-methoxy-2-((3-methoxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methylene)pentanamide

参考文献

1. Sardar Pasha SPB, et al. J Pharmacol Exp Ther. 2018 Aug 3. pii: jpet.118.248088.

APX2014 (APX 2014, APX-2014)

生物&药学活性

物理化学性质&存储条件

参考文献

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APX2014 (APX 2014, APX-2014)

生物&药学活性

物理化学性质&存储条件

参考文献

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