AOH1160 |CAS:2089314-57-6 Probechem Biochemicals

Chemical Structure : AOH1160

CAS No.: 2089314-57-6

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AOH1160 (AOH-1160;AOH 1160)

货号: PC-35301Not For Human Use, Lab Use Only.

AOH1160 (AOH-1160) is a potent, first-in-class, orally available small molecule inhibitor of Proliferating cell nuclear antigen (PCNA).

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

AOH1160 (AOH-1160) is a potent, first-in-class, orally available small molecule inhibitor of Proliferating cell nuclear antigen (PCNA).
AOH1160 selectively kills many types of cancer cells at below micromolar concentrations (mean GI50=330 nM) without causing significant toxicity to a broad range of non-malignant cells, interferes with DNA replication, blocks homologous recombination-mediated DNA repair, and causes cell cycle arrest.
AOH1160 suppresses tumor growth without causing significant side effects in mice, demostrates the potential as a broad-spectrum therapeutic agent for cancer treatment.

物理化学性质&存储条件

分子量	396.446
分子式	C25H20N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-oxo-2-((2-phenoxyphenyl)amino)ethyl)-1-naphthamide

参考文献

1. Gu L, et al. Clin Cancer Res. The anti-cancer activity of a first-in-class small molecule targeting PCNA. 2018 Jul 2. pii: clincanres.0592.2018.

AOH1160 (AOH-1160;AOH 1160)

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物理化学性质&存储条件

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AOH1160 (AOH-1160;AOH 1160)

生物&药学活性

物理化学性质&存储条件

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