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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Repair Protein -SU0383
SU0383

Chemical Structure : SU0383

CAS No.: 2598151-90-5

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SU0383 (SU 0383, SU-0383)

货号: PC-72025Not For Human Use, Lab Use Only.

SU0383 (SU 0383) is a potent, dual inhibitor of repair enzyme OGG1 and NUDT1 (MTH1) with IC50 of 34 nM and 490 nM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SU0383 (SU 0383) is a potent, dual inhibitor of repair enzyme OGG1 and NUDT1 (MTH1) with IC50 of 34 nM and 490 nM, respectively.
    SU0383 displayed low toxicity in two human cell lines at 10 uM, SU0383 increases sensitivity of tumor cells to oxidative stress.

    物理化学性质&存储条件

    分子量 626.732
    分子式 C33H34N6O5S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO (6.3 mg/mL)
    Chemical Name/SMILES

    N-(2-((2-Amino-5-methylpyrimidin-4-yl)oxy)ethyl)-4'-(N-(1-(cyclopropanecarbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)sulfamoyl)-[1,1'-biphenyl]-3-carboxamide

    参考文献

    1. Tahara YK, et al. ACS Chem Biol. 2019 Dec 20;14(12):2606-2615.

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