And1 inhibitor CH3 | And1 inhibitor | Probechem Biochemicals

Chemical Structure : And1 inhibitor CH3

CAS No.: 2451028-69-4

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And1 inhibitor CH3 (Acidic nucleoplasmic DNA-binding protein 1 inhibitor)

货号: PC-38504Not For Human Use, Lab Use Only.

And1 inhibitor CH3 is potent acidic nucleoplasmic DNA-binding protein 1 (And-1) inhibitor, reducess And‐1 expression level in IGROV1 cells with IC50 of 2.08 uM.

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5 mg	￥2980	In stock
10 mg	￥4580	In stock
25 mg	￥7580	In stock
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100 mg		Get quote

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生物&药学活性

And1 inhibitor CH3 is potent acidic nucleoplasmic DNA-binding protein 1 (And-1) inhibitor, reducess And‐1 expression level in IGROV1 cells with IC50 of 2.08 uM.
CH3 induces acidic nucleoplasmic DNA‐binding protein 1 (And‐1) degradation via the E3 ubiquitin ligase CUL4B‐mediated proteasome degradation pathway.
CH3 promotes the interaction between And‐1 and CUL4B by altering And‐1 conformation.
CH3 exhibits the significant inhibition in a broad range of cancer cells in vitro and in vivo.
CH3 (20 mg/kg and 40 mg/kg) reduced tumor growth of ovarian IGROV1 and breast MCF7 xenografts at both treated doses.
CH3 also could overcome cisplatin resistance in ovarian cancer.
And1 is an important factor for deoxyribonucleic acid (DNA) replication and repair, is overexpressed in many types of cancer but not in normal tissues.

物理化学性质&存储条件

分子量	304.961
分子式	C15H11BCl2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-5-(3,4-dichlorostyryl)benzo[c][1,2]oxaborol-1(3H)-ol

参考文献

1. Jing Li, et al. Clin Transl Med. 2021 Dec;11(12):e627.

And1 inhibitor CH3 (Acidic nucleoplasmic DNA-binding protein 1 inhibitor)

生物&药学活性

物理化学性质&存储条件

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And1 inhibitor CH3 (Acidic nucleoplasmic DNA-binding protein 1 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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