T2AA | PCNA inhibitor | Probechem Biochemicals

Chemical Structure : T2AA

CAS No.: 1380782-27-3

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T2AA (T2 amino alcohol)

货号: PC-72920Not For Human Use, Lab Use Only.

T2AA (T2 amino alcohol) is a small molecule proliferating cell nuclear antigen (PCNA) inhibitor, inhibits interaction of PCNA/PIP-box peptide with IC50 of 1 uM.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

T2AA (T2 amino alcohol) is a small molecule proliferating cell nuclear antigen (PCNA) inhibitor, inhibits interaction of PCNA/PIP-box peptide with IC50 of 1 uM.
T2AA also inhibits interaction of PCNA and full-length p21 protein.
T2AA abolished interaction of PCNA and DNA polymerase δ in cellular chromatin, arrested cancer cells in S-phase, inhibited growth of cancer cells with induction of early apoptosis.
T2AA significantly inhibited translesion DNA synthesis on a cisplatin-cross-linked template in cells, induced significant increase in phospho(Ser139) histone H2AX induction and cell growth inhibition combined with cisplatin.;

物理化学性质&存储条件

分子量	511.09
分子式	C15H15I2NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-(4-(2-amino-3-hydroxypropyl)-2,6-diiodophenoxy)phenol

参考文献

1. Actis M, et al. Bioorg Med Chem. 2013 Apr 1;21(7):1972-7.

2. Inoue A, et al. J Biol Chem. 2014 Mar 7;289(10):7109-7120.

3. Wilson RH, et al. DNA Repair (Amst). 2017 Feb;50:22-35.

4. Ohayon D, et al. J Exp Med. 2019 Nov 4;216(11):2669-2687.

T2AA (T2 amino alcohol)

生物&药学活性

物理化学性质&存储条件

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T2AA (T2 amino alcohol)

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物理化学性质&存储条件

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