BLM inhibitor 2

Chemical Structure : BLM inhibitor 2

加入收藏

货号: PC-72682Not For Human Use, Lab Use Only.

BLM inhibitor 2 is a specific inhibitor of BLM (Bloom syndrome protein) ATPase-coupled DNA helicase activity (IC50=2.2 uM) via the allosteric binding site.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

BLM inhibitor 2 is a specific inhibitor of BLM (Bloom syndrome protein) ATPase-coupled DNA helicase activity (IC50=2.2 uM) via the allosteric binding site.
BLM inhibitor 2 displays high selectivity over members of the RecQ-helicase family in ATP-turnover assays, including recombinant helicase domains (HD) from human WRN, human RecQ5 or E. coli helicase UvrD, and human RecQ1.
BLM inhibitor 2 is a non-competitive inhibitor, does not interfere with ATP-binding, unliker ML216.
BLM inhibitor 2 inhibits production of the single-stranded DNA product in a dose-dependent manner (IC50=1.8 uM) via inhibition of the helicase activity of BLM-HD.
BLM (Bloom syndrome protein) is a RECQ-family helicase involved in the dissolution of complex DNA structures and repair intermediates (BLM, WRN, RECQ1, RECQ4, and RECQ5 in humans).

物理化学性质&存储条件

分子量	401.499
分子式	C19H19N3O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2,3-dimethyl-5-sulfamoylphenyl)-4-(2-methylthiazol-4-yl)benzamide

参考文献

1. Xiangrong Chen, et al. Elife. 2021 Mar 1;10:e65339.

BLM inhibitor 2

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

BLM inhibitor 2

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.