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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Repair Protein -NSC37215
NSC37215

Chemical Structure : NSC37215

CAS No.: 6274-87-9

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NSC37215 (NSC 37215)

货号: PC-26961Not For Human Use, Lab Use Only.

NSC37215 is an effective small molecule inhibitor of three prime repair exonuclease 1 (TREX1) with IC50 of 4.72 uM and 30.32 uM for human and mouse TREX1 respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NSC37215 is an effective small molecule inhibitor of three prime repair exonuclease 1 (TREX1) with IC50 of 4.72 uM and 30.32 uM for human and mouse TREX1 respectively.
    NSC37215 exhibits a lower Kd with hTREX1 than that with mTREX1.
    NSC37215 inhibits mTREX1 in binding DNA in EMSA assays, inhibits the nuclease activity of TREX1 by interfering with DNA binding.

    物理化学性质&存储条件

    分子量 484.46
    分子式 C24H17N2NaO6S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-Naphthalenesulfonic acid, 7-[[4-(benzoylamino)benzoyl]amino]-4-hydroxy-, sodium salt

    参考文献

    1. Xing C, et al. Cancer Res. 2025 Aug 1;85(15):2858-2875.

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