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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Repair Protein -MWAC-1657
MWAC-1657

Chemical Structure : MWAC-1657

CAS No.: 2525504-80-5

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MWAC-1657 (MWAC1657 )

货号: PC-27257Not For Human Use, Lab Use Only.

MWAC-1657 is a highly potent, selective three-prime Repair EXonuclease 1 (TREX1) inhibitor with IC50 of 154 nM (hTREX1), >100-fold selectivity toward hTREX1 over hTREX2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MWAC-1657 is a highly potent, selective three-prime Repair EXonuclease 1 (TREX1) inhibitor with IC50 of 154 nM (hTREX1), >100-fold selectivity toward hTREX1 over hTREX2.

物理化学性质&存储条件

分子量 399.45
分子式 C21H23F2N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(3,4-difluorophenyl)-1-(6-(1-ethyl-3-methyl-1H-pyrazol-4-yl)pyrazin-2-yl)piperidin-4-ol

参考文献

1. Hernandez PC, et al. NAR Mol Med. 2026 Jun 19;3(3):ugag033.

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