TREX1-IN-3

Chemical Structure : TREX1-IN-3

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货号: PC-26959Not For Human Use, Lab Use Only.

TREX1-IN-3 (Compound 95) is a potent dual inhibitor of DNA nucleases TREX1 and TREX2 with IC50 of <0.1 μM and < 1 μM, and has EC50 for HCT116 cells of < 1 μM.

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生物&药学活性

TREX1-IN-3 (Compound 95) is a potent dual inhibitor of DNA nucleases TREX1 and TREX2 with IC50 of <0.1 μM and < 1 μM, and has EC50 for HCT116 cells of < 1 μM.

物理化学性质&存储条件

分子量	490.90
分子式	C24H19ClN6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(((2-chlorophenyl)(3-cyanophenyl)methyl)(methyl)amino)-5-hydroxy-N-(isoxazol-4-yl)-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide

参考文献

1. Patent WO2021016317 A1, Pyrimidinediones as modulators of TREX1 and their preparation. Compound 95.

TREX1-IN-3

生物&药学活性

物理化学性质&存储条件

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TREX1-IN-3

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物理化学性质&存储条件

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