| Cat. No. |
Product Name |
Information |
| PC-24053 |
ORF9b homodimerization inhibitor EN300
ORF9b inhibitor
|
ORF9b homodimerization inhibitor EN300 is a small molecule inhibitor of ORF9b homodimerization, inhibits ORF9b-ORF9b homotypic interaction, inhibits activation of caspase-1 in A549.ORF9b and THP-1.ORF9b cells with IC50 of 0.85 and 17 nM respectively. |
| PC-23805 |
FLIPinBγ
c-FLIPL inhibitor
|
FLIPinBγ is a first-in class, specific small molecule inhibitor of c-FLIPL in the caspase-8/c-FLIPL heterodimer, promotes CD95L- and TRAIL-mediated loss of cell viability and cell death. |
| PC-23804 |
FLIPinB
c-FLIPL inhibitor
|
FLIPinB is a first-in class, specific small molecule inhibitor of c-FLIPL in the caspase-8/c-FLIPL heterodimer, promotes CD95L- and TRAIL-mediated loss of cell viability and cell death. |
| PC-22972 |
Pralnacasan
Caspase-1 inhibitor
|
Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active caspase 1 (interleukin-1β converting enzyme, ICE) inhibitor with Ki of 1.4 nM, inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. |
| PC-22971 |
CIB-1476
pro-caspase-1 inhibitor
|
CIB-1476 is an irreversible covalent inhibitor of pro-caspase-1 with IC50 of 0.65 uM, covalently targets pro-caspase-1 Cys285 and Cys397, inhibits NLRP3 inflammasome activation. |
| PC-22752 |
Ac-YVAD-cmk
Caspase-1 inhibitor
|
Ac-YVAD-cmk is a tetrapeptide, selective caspase-1 (interleukin-1 beta converting enzyme, ICE) inhibitor with neuroprotective and anti-inflammatory effects, inhibits pyroptosis (caspase-1-activated cell death). |
| PC-22751 |
Z-YVAD-FMK
Caspase-1 inhibitor
|
Z-YVAD-FMK is a specific, cell-permeable and irreversible caspase-1 inhibitor with anti-inflammatory and anti-tumor activities. |
| PC-22740 |
Procaspase-3 activator PAC‐1
Procaspase-3 activator
|
PAC-1 is a small-molecule activator of procaspase-3 to caspase-3, induces apoptosis in cancerous cells, induces apoptosis in HL-60 cells with EC50 of 2.08 uM. |
| PC-22034 |
CZL80
Caspase-1 inhibitor
|
Caspase-1 inhibitor CZL80 is a potent, selective, brain‐penetrable Caspase-1 inhibitor with IC50 of 0.01 uM. |
