| Cat. No. |
Product Name |
Information |
| PC-62209 |
Procaspase-3 activator 1541
Procaspase-3/6 activator
|
Procaspase-3 activator 1541 is a small-molecule inducer of cell death that noncovalently self-assembles into chemical fibrils and activates procaspase-3 and 6 in vitro (EC50=2.4 and 2.8 uM). |
| PC-61354 |
IDN-7314
pan-Caspase inhibitor
|
IDN-7314 is a potent, orally active, and irreversible pan-Caspase protease inhibitor with IC50 of <0.08 to 7 nM for inhibition of activated caspase 3, 6 and 8. |
| PC-70208 |
NWL-117
Caspase-6 inhibitor
|
NWL-117 is a potent, BBB penetrant Caspase-6 inhibitor with IC50 of 192 nM, also inhibits Caspase-4/8/9/10 with IC50 of 0.1-0.8 uM. |
| PC-60171 |
KEA1-97
Thioredoxin-Caspase 3 inhibitor
|
KEA1-97 (KEA 1-97) is a small molecule that disrupts the interaction of thioredoxin with caspase 3. |
| PC-27874 |
Ac-LESD-AMC
Caspase-8 substrate
|
Ac-LESD-AMC is a caspase-8 fluorogenic substrate (relative Kcat/K M = 0.15) that most efficiently hydrolyzed by caspase-8 and caspase-10, 10-fold faster than inflammatory caspases-1, -4, and -5. |
| PC-27754 |
Saikosaponin C
Caspase-3 inhibitor
|
Saikosaponin C is a natural compound purified from the traditional Chinese herb of Radix Bupleuri, exhibits anti-HBV replication activity and inhibits by targeting HNF1α and HNF4αHBV pgRNA synthesis, significantly inhibits LPS-induced apoptotic cell death in HUVECs via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation. |
| PC-26675 |
Ac-DEVD-CHO
Caspase-3 inhibitor
|
Ac-DEVD-CHO is a specific inhibitor of apoptosis and reversible caspase-3 inhibitor with Ki of 0.23 nM. |
| PC-26191 |
Nitrosonisoldipine
Inflammatory caspases inhibitor
|
Nitrosonisoldipine is a photodegradation product of calcium channel inhibitor nisoldipine, is a selective inhibitor of inflammatory caspases, inhibits noncanonical pyroptosis mediated by caspase-11 or caspase-4 and canonical pyroptosis mediated by caspase-1. |
| PC-25488 |
Z-DQMD-FMK
Caspase-3 inhibitor
|
Z-DQMD-FMK is a specific inhibitor of caspase-3, inhibits MG132-induced small cell lung cancer cell death in vitro. |
| PC-25487 |
Z-VEID-FMK
Caspase-6 inhibitor
|
Z-VEID-FMK (Z-VE(OMe)ID(OMe)-FMK) is a specific, irreversible caspase-6 inhibitor, mimicks the effects of caspase-6 deficiency and prevents the cleavage of lamin A, significantly decreases caspase-6 activity and the oxLDL-induced DNA fragmentation and cell apoptosis. |
| PC-24912 |
MMPSI
Caspase 3/Caspase 7 inhibitor
|
MMPSI is a potent and selective, non-peptide caspase 3/7 inhibitor with Ki app of 0.06 uM and 0.17 uM respective, exhibits >100-fold selectivity over all other family members except caspase 9 (Ki app=3.1 uM). |
| PC-24911 |
Ac-DNLD-CHO
Caspase-3 inhibitor
|
Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is a potent, selective, reversible Caspase-3 inhibitor with IC50 of 9.89 nM, Ki app of 0.68 nM respectively. |
