NH-23-C2 | Caspase-2 inhibitor | Probechem Biochemicals

Chemical Structure : NH-23-C2

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NH-23-C2 (Caspase-2 inhibitor NH-23-C2)

货号: PC-72960Not For Human Use, Lab Use Only.

NH-23-C2 (Caspase-2 inhibitor NH-23-C2) is a potent, selective and cell-permeable endogenous caspase-2 inhibitor, does not block caspase-3 or caspase-8.

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生物&药学活性

NH-23-C2 (Caspase-2 inhibitor NH-23-C2) is a potent, selective and cell-permeable endogenous caspase-2 inhibitor, does not block caspase-3 or caspase-8.
NH-23-C2 displays off-reactivity with cysteine and threonine proteases (cathepsins B, L, V, S).
HCT116 cells were preincubated with NH-23-C2 inhibitor, MDM-2 cleavage was inhibited in a concentration-dependent manner (IC50 =3.11 μM).
NH-23-C2 selectively block caspase-2 activity and caspase-2-mediated MDM-2 cleavage.

物理化学性质&存储条件

分子量	845.903
分子式	C43H51N5O13
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(O)CCC[C@H](NC([C@H]1NC2=C(C=CC=C2)C1)=O)C(N[C@@H]([C@@H](OCC3=CC=CC=C3)C)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(COC(C4=C(C)C=CC=C4C)=O)=O)=O)=O)=O

参考文献

1. Marcin Poreba, et al. Cell Death Differ. 2019 Dec;26(12):2695-2709.

NH-23-C2 (Caspase-2 inhibitor NH-23-C2)

生物&药学活性

物理化学性质&存储条件

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NH-23-C2 (Caspase-2 inhibitor NH-23-C2)

生物&药学活性

物理化学性质&存储条件

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