CZL80 | Caspase-1 inhibitor | Probechem Biochemicals

Chemical Structure : CZL80

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CZL80 (Caspase-1 inhibitor CZL80)

货号: PC-22034Not For Human Use, Lab Use Only.

Caspase-1 inhibitor CZL80 is a potent, selective, brain‐penetrable Caspase-1 inhibitor with IC50 of 0.01 uM.

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1 g		Get quote

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生物&药学活性

Caspase-1 inhibitor CZL80 is a potent, selective, brain‐penetrable Caspase-1 inhibitor with IC50 of 0.01 uM.
CZL80 markedly reduced neuronal excitability and incidence of febrile seizures (FS) generation in neonatal mice.
CZL80 relieves later enhanced epileptogenic susceptibility in adult mice.
CZL80 is devoid of acute diazepam‐like respiratory depression and chronic liver toxicity.
CZL80 promotes the neurological recovery in PIS by inhibiting Caspase-1 within a long therapeutic time-window in mice with progressive ischemic stroke (PIS).

物理化学性质&存储条件

分子量	366.39
分子式	C19H14N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-(thiophene-2-carboxamido)benzamido)benzoic acid

参考文献

1. Tang Y, et al. Br J Pharmacol. 2020 Aug;177(15):3519-3534.

2. Pan L, et al. Acta Pharmacol Sin. 2022 Nov;43(11):2817-2827.

CZL80 (Caspase-1 inhibitor CZL80)

生物&药学活性

物理化学性质&存储条件

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CZL80 (Caspase-1 inhibitor CZL80)

生物&药学活性

物理化学性质&存储条件

参考文献

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