Procaspase-6 inhibitor 12 | Procaspase-6 inhibitor | Probechem Biochemicals

Chemical Structure : Procaspase-6 inhibitor 12

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Procaspase-6 inhibitor 12 (Procaspase-6-IN-12)

货号: PC-73050Not For Human Use, Lab Use Only.

Procaspase-6 inhibitor 12 is a small molecule, noncovalent, allosteric inhibitor of procaspase-6 with KD of 0.47 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Procaspase-6 inhibitor 12 is a small molecule, noncovalent, allosteric inhibitor of procaspase-6 with KD of 0.47 uM.
Procaspase-6 inhibitor 12 binds to pro-C6 at the dimer interface and contacts amino acids Y198, T199 and E214.
Procaspase-6 inhibitor 12 significantly stabilizes procaspase-6.
Procaspase-6 inhibitor 12 prevents the activation of the Caspase-6 zymogen by mHTT1–586 in COS-7 cells.

物理化学性质&存储条件

分子量	296.305
分子式	C16H13FN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-fluoro-2-(((3-(pyrimidin-2-yl)pyridin-2-yl)amino)methyl)phenol

参考文献

1. Jeremy Murray, et al. ChemMedChem. 2014 Jan;9(1):73-7, 2.

2. Ehrnhoefer DE, et al. Cell Chem Biol. 2019 Sep 19;26(9):1295-1305.e6.

Procaspase-6 inhibitor 12 (Procaspase-6-IN-12)

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物理化学性质&存储条件

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Procaspase-6 inhibitor 12 (Procaspase-6-IN-12)

生物&药学活性

物理化学性质&存储条件

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