Raptinal

Chemical Structure : Raptinal

CAS No.: 1176-09-6

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货号: PC-21768Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
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100 mg		Get quote

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生物&药学活性

Raptinal is a small molecule rapid apoptosis inducer, initiates intrinsic pathway caspase-dependent apoptosis in multiple cell lines, also inhibits the activity of caspase-activated Pannexin 1 (PANX1).
Raptinal rapidly trigger apoptosis by promoting the release of cytochrome c from the mitochondria and subsequently activating the intrinsic apoptotic pathway.
Raptinal is very effective at inducing apoptosis in a variety of different cell types in vitro and in vivo.
Raptinal inhibits cleavage-activated PANX1 via a mechanism distinct to other well-described PANX1 inhibitors such as carbenoxolone and trovafloxacin.
Raptinal also interferes with PANX1-regulated apoptotic processes including the release of the 'find-me' signal ATP, the formation of apoptotic cell-derived extracellular vesicles, as well as NLRP3 inflammasome activation.
Raptinal is the first compound that can simultaneously induce apoptosis and inhibit PANX1 channels.

物理化学性质&存储条件

分子量	386.45
分子式	C28H18O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9H,9'H-[9,9'-Bifluorene]-9,9'-dicarbaldehyde

参考文献

1. Palchaudhuri R, et al. Cell Rep. 2015 Dec 1;13(9):2027-36.

2. Heimer S, et al. Cell Death Dis. 2019 Jul 19;10(8):556.

3. Santavanond JP, et al. Cell Death Dis. 2024 Feb 9;15(2):123.

Raptinal

生物&药学活性

物理化学性质&存储条件

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Raptinal

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