| Cat. No. |
Product Name |
Information |
| PC-62210 |
Procaspase-3 activator 1541B
Procaspases-3 activator
|
Procaspase-3 activator 1541B is a specific, small molecule activator of procaspases-3 with EC50 of 1.3 uM. |
| PC-62209 |
Procaspase-3 activator 1541
Procaspase-3/6 activator
|
Procaspase-3 activator 1541 is a small-molecule inducer of cell death that noncovalently self-assembles into chemical fibrils and activates procaspase-3 and 6 in vitro (EC50=2.4 and 2.8 uM). |
| PC-61354 |
IDN-7314
pan-Caspase inhibitor
|
IDN-7314 is a potent, orally active, and irreversible pan-Caspase protease inhibitor with IC50 of <0.08 to 7 nM for inhibition of activated caspase 3, 6 and 8. |
| PC-70208 |
NWL-117
Caspase-6 inhibitor
|
NWL-117 is a potent, BBB penetrant Caspase-6 inhibitor with IC50 of 192 nM, also inhibits Caspase-4/8/9/10 with IC50 of 0.1-0.8 uM. |
| PC-60171 |
KEA1-97
Thioredoxin-Caspase 3 inhibitor
|
KEA1-97 (KEA 1-97) is a small molecule that disrupts the interaction of thioredoxin with caspase 3. |
| PC-24253 |
z-VAD-fmk
Pan caspase inhibitor
|
z-VAD-fmk (Z-VAD(OH)-FMK) is a well-known small molecule pan-caspase inhibitor. |
| PC-24252 |
Ac-LEHD-cmk
Caspase-9 inhibitor
|
Ac-LEHD-cmk is a specific caspase 9 inhibitor. |
| PC-24251 |
z-LEHD-FMK
Caspase-9 inhibitor
|
z-LEHD-FMK is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis, exhibits the neuroprotective effect in rat model of spinal cord trauma. |
| PC-24250 |
Ac-FLTD-CMK
Caspase-1/4/5 inhibitor
|
Ac-FLTD-CMK is a gasdermin D (GSDMD)-derived inhibitor and specific inflammatory caspases inhibitor for caspases-1 (IC50=46.7 nM), caspases-4 (IC50=1.49 μM), caspases-5 (IC50=329 nM), does not inhibit apoptotic caspases such as caspase-3. |
| PC-24249 |
Ac-LESD-CMK
Caspase-8 inhibitor
|
Ac-LESD-CMK is a potent, selective inhibitor of caspase-8 and its homolog caspase-10 with IC50 of 50 nM and 520 nM respectively, Ac-LESD-CMK is a potent and selective inhibitor of caspases-8, -10, and -5. |
| PC-24248 |
z-IETD-FMK
Caspase-8 inhibitor
|
Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor with IC50 of 350 nM. |
| PC-24054 |
ORF9b homodimerization inhibitor Y600
ORF9b inhibitor
|
ORF9b homodimerization inhibitor Y600 is a small molecule inhibitor of ORF9b homodimerization, inhibits ORF9b-ORF9b homotypic interaction, inhibits activation of caspase-1 in A549.ORF9b and THP-1.ORF9b cells with IC50 of 1 and 4 nM respectively. |
