ORF9b homodimerization inhibitor EN300

Chemical Structure : ORF9b homodimerization inhibitor EN300

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货号: PC-24053Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

ORF9b homodimerization inhibitor EN300 is a small molecule inhibitor of ORF9b homodimerization, inhibits ORF9b-ORF9b homotypic interaction, inhibits activation of caspase-1 in A549.ORF9b and THP-1.ORF9b cells with IC50 of 0.85 and 17 nM respectively.
EN300 abrogates cytokine release in THP-1 cells, restores IFN-I responses compromised by ORF9b.
EN300 potentiates IFN-I responses upon SARS-CoV-2 infection of A549 lung carcinoma cells.

物理化学性质&存储条件

分子量	244.27
分子式	C14H13FN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-amino-2-fluorophenyl)-2-phenylacetamide

参考文献

1. Zodda E, et al. J Med Virol. 2025 Feb;97(2):e70145.