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首页-小分子抑制剂&激动剂-Apoptosis-Caspase-Pralnacasan
Pralnacasan

Chemical Structure : Pralnacasan

CAS No.: 192755-52-5

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Pralnacasan (VX-740, HMR 3480)

货号: PC-22972Not For Human Use, Lab Use Only.

Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active caspase 1 (interleukin-1β converting enzyme, ICE) inhibitor with Ki of 1.4 nM, inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active caspase 1 (interleukin-1β converting enzyme, ICE) inhibitor with Ki of 1.4 nM, inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ.

物理化学性质&存储条件

分子量 523.55
分子式 C26H29N5O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxamide, N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]octahydro-9-[(1-isoquinolinylcarbonyl)amino]-6,10-dioxo-, (1S,9S)-

参考文献

1. Rudolphi K, et al. Osteoarthritis Cartilage. 2003 Oct;11(10):738-46

2. Loher F, et al. J Pharmacol Exp Ther. 2004 Feb;308(2):583-90.

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