CIB-1476 | pro-caspase-1 inhibitor | Probechem Biochemicals

Chemical Structure : CIB-1476

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CIB-1476 (CIB1476)

货号: PC-22971Not For Human Use, Lab Use Only.

CIB-1476 is an irreversible covalent inhibitor of pro-caspase-1 with IC50 of 0.65 uM, covalently targets pro-caspase-1 Cys285 and Cys397, inhibits NLRP3 inflammasome activation.

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生物&药学活性

CIB-1476 is an irreversible covalent inhibitor of pro-caspase-1 with IC50 of 0.65 uM, covalently targets pro-caspase-1 Cys285 and Cys397, inhibits NLRP3 inflammasome activation.
CIB-1476 has no effect on pro-caspase-1 and pro-IL-1β protein expression, but potently inhibited the expression of the p20 fragment of caspase-1 and mature IL-1β stimulated by various NLRP3 agonists.
CIB-1476 significantly inhibited the release of IL-1β and IL-18 in LPS and nigericin-stimulated J774A.1 cells in a concentration-dependent manner. Meanwhile, CIB-1476 also effectively inhibited ATP- and MSU-induced NLRP3 inflammasome activation.
CIB-1476 blocks the noncanonical function of caspase-1 in the suppression of priming and assembly of the NLRP3 inflammasome.
CIB-1476 effectively suppressed pyroptosis during NLRP3 inflammasome activation.
CIB-1476 effectively inhibited NLRP3 inflammasome activation in vivo against caspase-1-mediated inflammation in mice.

物理化学性质&存储条件

分子量	520.60
分子式	C28H28N2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1'-benzyl 6-(tert-butyl) 4-isothiocyanato-5'-methoxy-2'-oxospiro[cyclohexane-1,3'-indolin]-2-ene-1',6-dicarboxylate

参考文献

1. Cao D, et al. J Med Chem. 2024 Aug 19. doi: 10.1021/acs.jmedchem.4c01558.

CIB-1476 (CIB1476)

生物&药学活性

物理化学性质&存储条件

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CIB-1476 (CIB1476)

生物&药学活性

物理化学性质&存储条件

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