FLIPinB

Chemical Structure : FLIPinB

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货号: PC-23804Not For Human Use, Lab Use Only.

FLIPinB is a first-in class, specific small molecule inhibitor of c-FLIPL in the caspase-8/c-FLIPL heterodimer, promotes CD95L- and TRAIL-mediated loss of cell viability and cell death.

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生物&药学活性

FLIPinB is a first-in class, specific small molecule inhibitor of c-FLIPL in the caspase-8/c-FLIPL heterodimer, promotes CD95L- and TRAIL-mediated loss of cell viability and cell death.
FLIPinB enhances CD95L-/TRAIL-mediated loss of cell viability in Jurkat, HeLa-CD95 and HeLa-CD95-FL cells, increases caspase activation.
Co-treatment with FLIPinBγ increased the rate of CD95L-induced apoptotic cell death in HeLa-CD95-FL cells.
FLIPinB sensitizes the cell death in pancreatic cancer cells induced by combinatorial treatment with Death Ligand (DL), gemcitabine and Mcl-1 inhibitor S63845.
c-FLIPL, the long isoform of c-FLIP, is a DED-containing protein and a key regulator of the extrinsic apoptosis pathway. DISC comprises DR, FADD, procaspase-8/10 and c-FLIPL/S/R proteins, DISC serves as a platform for procaspase-8 activation, which takes place upon its oligomerization in the death effector domain (DED)-filaments, initiating the apoptotic destruction of the cell.

物理化学性质&存储条件

分子量	514.60
分子式	C29H26N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-([1,1'-biphenyl]-4-carboxamido)ethyl 3-(N-benzylsulfamoyl)benzoate

参考文献

1. König C, et al. Commun Biol. 2025 Jan 3;8(1):4.

2. Hillert LK, et al. Cell Death Differ. 2020 Jul;27(7):2117-2130.

FLIPinB

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FLIPinB

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