z-IETD-FMK | Caspase-8 inhibitor | Probechem Biochemicals

Chemical Structure : z-IETD-FMK

CAS No.: 210344-98-2

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z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK)

货号: PC-24248Not For Human Use, Lab Use Only.

Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor with IC50 of 350 nM.

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5 mg	￥2380	In stock
10 mg	￥3880	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor with IC50 of 350 nM.
Z-IETD-FMK induces concentration-dependent inhibition of only TNF alpha-stimulated apoptosis.

物理化学性质&存储条件

分子量	654.69
分子式	C30H43FN4O11
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Threoninamide, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester

参考文献

1. Martin DA, et al. J Biol Chem. 1998 Feb 20;273(8):4345-9.

2. Mocanu MM, et al. Br J Pharmacol. 2000 May;130(2):197-200.

3. Cowburn AS, et al. Blood. 2005 Apr 1;105(7):2970-2.

4. Bourne CM, et al. bioRxiv [Preprint]. 2025 Feb 27:2025.02.23.639785.

z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK)

生物&药学活性

物理化学性质&存储条件

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z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK)

生物&药学活性

物理化学性质&存储条件

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