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首页-小分子抑制剂&激动剂-Apoptosis-Caspase-Ac-LESD-CMK
Ac-LESD-CMK

Chemical Structure : Ac-LESD-CMK

CAS No.:

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Ac-LESD-CMK (N-acetyl-Leu-Glu-Ser-Asp-chloromethylketone)

货号: PC-24249Not For Human Use, Lab Use Only.

Ac-LESD-CMK is a potent, selective inhibitor of caspase-8 and its homolog caspase-10 with IC50 of 50 nM and 520 nM respectively, Ac-LESD-CMK is a potent and selective inhibitor of caspases-8, -10, and -5.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Ac-LESD-CMK is a potent, selective inhibitor of caspase-8 and its homolog caspase-10 with IC50 of 50 nM and 520 nM respectively, Ac-LESD-CMK is a potent and selective inhibitor of caspases-8, -10, and -5.
Ac-LESD-CMK also is an efficient inhibitor of caspase-5 with IC50 of 2 uM.
Ac-LESD-CMK weakly inhibits the executioner caspases.
Ac-LESD-CMK inhibits the extrinsic apoptotic initiator caspases over 100 fold more potently than Ac-FLTD-CMK。
Ac-LESD-CMK inhibits caspase-1 with IC50 of 3.36 uM.
Ac-LESD-CMK efficiently blocks caspase-5 activity (IC50 = 2 μM) better than Ac-FLTD-CMK (IC50 = 15 μM).
Ac-LESD-CMK weakly inhibits mouse caspase-11 and the executioner caspases-3, -6, and -7.
Ac-LESD-CMK strongly inhibits activation of caspase-8-dependent cell death and modestly inhibits cell death triggered by inflammasome activation.

物理化学性质&存储条件

分子量 564.97
分子式 C22H33ClN4O11
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4S,7S,10S,13S)-7-(2-carboxyethyl)-13-(3-chloro-2-oxopropanoyl)-10-(hydroxymethyl)-4-isobutyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid

参考文献

1. Bourne CM, et al. bioRxiv [Preprint]. 2025 Feb 27:2025.02.23.639785.

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