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首页-小分子抑制剂&激动剂-Apoptosis-Caspase-Ac-FLTD-CMK
Ac-FLTD-CMK

Chemical Structure : Ac-FLTD-CMK

CAS No.: 2376255-48-8

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Ac-FLTD-CMK

货号: PC-24250Not For Human Use, Lab Use Only.

Ac-FLTD-CMK is a gasdermin D (GSDMD)-derived inhibitor and specific inflammatory caspases inhibitor for caspases-1 (IC50=46.7 nM), caspases-4 (IC50=1.49 μM), caspases-5 (IC50=329 nM), does not inhibit apoptotic caspases such as caspase-3.

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1 mg ￥2380 In stock
5 mg ￥5880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ac-FLTD-CMK is a gasdermin D (GSDMD)-derived inhibitor and specific inflammatory caspases inhibitor for caspases-1 (IC50=46.7 nM), caspases-4 (IC50=1.49 μM), caspases-5 (IC50=329 nM), does not inhibit apoptotic caspases such as caspase-3.

物理化学性质&存储条件

分子量 569.05
分子式 C26H37ClN4O8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4S,7S,10S,13S)-4-Benzyl-13-(2-chloroacetyl)-10-((R)-1-hydroxyethyl)-7-isobutyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid

参考文献

1. Jie Yang, et al. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6792-6797.

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