NS3694 | Caspase inhibitor | Probechem Biochemicals

Chemical Structure : NS3694

CAS No.: 426834-38-0

加入收藏

NS3694 (NS 3694)

货号: PC-49742Not For Human Use, Lab Use Only.

NS3694 (NS 3694) is a specific cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation, blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with IC50 of 50 uM.

规格	价格	库存
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

NS3694 (NS 3694) is a specific cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation, blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with IC50 of 50 uM.
NS3694 inhibits cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates.
NS3694 inhibits the association of caspase 9 to Apaf-1.
NS3694 blocks the formation of the 700-kDa apoptosome complex. NS3694 (10-100 uM) inhibits TNF-induced effector caspase activation and apoptosis in MCF-casp3 cells.
NS3694 inhibits TNF- and staurosporine-induced effector caspase activation and TNF-induced apoptosis in ME-180as cells.
NS3694 does not inhibit FasL-induced DEVDase activity or FasL-induced cytotoxicity in SKW6.4 cells.

物理化学性质&存储条件

分子量	358.70
分子式	C15H10ClF3N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-chloro-2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzoic acid

参考文献

1. Ulrik Lademann, et al. Mol Cell Biol. 2003 Nov;23(21):7829-37.

2. Zhao CQ, et al. Age (Dordr). 2010 Jun;32(2):161-77.

NS3694 (NS 3694)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

NS3694 (NS 3694)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.