| Cat. No. |
Product Name |
Information |
| PC-43340 |
I-BET762
BET inhibitor
|
I-BET762 (GSK-525762A, Molibresib) is a highly potent, selective inhibitor of BET family proteins BRD2, BRD3 and BRD4 with IC50 of 32.5-42.5 nM, does not interact with other bromodomain-containing proteins (BAZ2B, ATAD2, CREBBP and PCAF). |
| PC-63219 |
TRIM24 inhibitor X
TRIM24 inhibitor
|
TRIM24 inhibitor X is a potent TRIM24 bromodomain inhibitor for synthesis dTRIM24.. |
| PC-63218 |
IACS-7e
TRIM24 inhibitor
|
IACS-7e is a potent TRIM24 bromodomain inhibitor with IC50 of 217.8 nM (TRIM24 ligand displacement). |
| PC-63216 |
IACS-9571
TRIM24 inhibitor
|
IACS-9571 is a potent, selective dual TRIM24-BRPF1 bromodomain inhibitor with Kd of 31 and 14 nM, respectively. |
| PC-43027 |
BET-BAY 002
BET inhibitor
|
BET-BAY 002 is a potent BET bromodomain inhibitor, shows efficacy in a multiple myeloma model. |
| PC-43338 |
JQ1
BET inhibitor
|
(+)-JQ-1 (JQ1) is a potent, selective, cell-permeable BET bromodomain inhibitor with IC50 of 77 nM/33 nM for BRD4 BD1 and BD2, respectively. |
| PC-62986 |
AZD5153
BET inhibitor
|
AZD5153 is a potent, selective, bivalent and orally available BET/BRD4 bromodomain with IC50 of 5 nM. |
| PC-62938 |
BRD9-IN-28
BRD9/BRD7 inhibitor
|
BRD9-IN-28 is a highly potent and selective BRD7/9 bromodomain inhibitor with pIC50 of 6.9, Kd of 68 nM for BRD9. |
| PC-62845 |
GNE-375
BRD9 inhibitor
|
GNE-375 (GNE375) is a potent, selective BRD9 inhibitor with IC50 of 5 nM, displays >480-fold selectivity over BRD4, CECR2, and TAF1. |
| PC-62636 |
FL-411
BRD4 inhibitor
|
FL-411 is a novel small-molecule inhibitor of BRD4, induces ATG5-dependent autophagy-associated cell death (ACD) by blocking BRD4-AMPK interaction and activating AMPK-mTOR-ULK1-modulated autophagic pathway in breast cancer cells. |
| PC-62550 |
GNE-886
CECR2 inhibitor
|
GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM. |
| PC-62511 |
CPI203
BET inhibitor
|
CPI 203 (TEN 010, JQ-2, RG-6146, RO6870810) is a primary amide analog of (+)-JQ1and a BET bromodomain inhibitor that shows cytotoxicity against MCL cell lines with GI50 of 0.1-0.3 uM. |
