| Cat. No. |
Product Name |
Information |
| PC-21993 |
pNPS14
pBRD4 inhibitor
|
pNPS14 is a small molecule inhibitor of phospho-BRD4 (pBRD4) with IC50 of 3.39 uM, binds to phospho-NPS (pNPS) and disrupts HPV E2-BRD4 interaction, effectively inhibits HPV ecDNA replication. |
| PC-21985 |
CBP bromodomain inhibitor 29
CBP bromodomain inhibitor
|
CBP-IN-29 is a potent, selective CBP bromodomain inhibitor with IC50 of 2.2 nM, displays exquisite selectivity over BRD4(1) (IC50=23 uM) and the broader bromodomain family. |
| PC-21984 |
CBP bromodomain inhibitor 27
CBP bromodomain inhibitor
|
CBP-IN-27 is a potent, selective CBP bromodomain inhibitor with IC50 of 3.6 nM, displays exquisite selectivity over BRD4(1) (IC50=11 uM) and the broader bromodomain family. |
| PC-21929 |
IACS-9571 hydrochloride
TRIM24 inhibitor
|
IACS-9571 hydrochloride is a potent, selective dual TRIM24-BRPF1 bromodomain inhibitor with Kd of 31 and 14 nM, respectively. |
| PC-21739 |
ZL0590
BRD4 BD1 inhibitor
|
ZL0590 is a potent, orally active, BRD4 BD1-selective inhibitor with IC50 of 90 nM for human BRD4 BD1. |
| PC-21732 |
XL-126
BET BD1 inhibitor
|
XL-126 (XL126) is a potent BD1-selective BET inhibitor with SPR binding KD value of 8.9 nM, has 185-fold BD1/BD2 selectivity. |
| PC-21726 |
DUAL946
BET/HDAC inhibitor
|
DUAL946 is a sub-micromolar inhibitor of both BET and class I & IIb HDAC proteins with IC50 of 0.05/0.25/0.42/14.13/34.89 uM for BRD4/HDAC1/HDAC2/HDAC5/HDAC7/HDAC9, respectively. |
| PC-21651 |
DW-71177
BET BD1 inhibitor
|
DW-71177 (DW71177) is a potent and BD1-selective BET inhibitor with ITC KD of 6.7 nM (BRD4-BD1), 20-fold selective over BRD4-BD2, exhibits strong antileukemic activity. |
| PC-21331 |
LT052
BET BD1 inhibitor
|
LT052 is a potent, selective BET BD1 bromodomain inhibitor with IC50 of 88 nM, 138-fold selectivity for BRD4 BD1 over BRD4 BD2. |
| PC-21330 |
MS436
BRD4 BD1 inhibitor
|
MS436 is a potent, selective BRD4 BD1 bromodomain inhibitor with Ki values of 30-50 nM, 10-fold selectivity over the BD2. |
| PC-21329 |
GSK023
BET BD1 inhibitor
|
GSK023 is a potent, selective BET BD1 domain inhibitor with pIC50 of 7.8 against BRD4 BD1, >100-fold selective over BD2. |
| PC-21303 |
CN210
BET bromodomain inhibitor
|
CN210 is a quinazoline-based BET family inhibitor with Kd value of 70 nM for BRD4 (BD1,2) and IC50 of 0.94 uM in MV4-11 viability assay. |
