| Cat. No. |
Product Name |
Information |
| PC-42168 |
CPI-637
CBP/p300 inhibitor
|
CPI-637 is a potent and selective, cell-active CBP/EP300 bromodomain inhibitor with CBP BRET EC50 of 0.03 uM. |
| PC-43808 |
I-BET726
BET inhibitor
|
I-BET726 (GSK1324726A) is a potent and selective inhibitor of BET bromodomain with IC50 of 41 nM/31 nM/22 nM for BRD2/BRD3/BRD4 respectively. |
| PC-42230 |
TPOP146
CBP/p300 inhibitor
|
TPOP146 is a potent and selective CBP/p300 bromodomain inhibitor with Kd of 134 nM for CBP bromodomain, displays excellent selectivity over other bromodomains (>30-fold over BRD4 (1)). |
| PC-42029 |
Mivebresib
BET inhibitor
|
Mivebresib (ABBV-075) is a potent and orally available BET bromodomain inhibitor with Ki of 1.0, 12.2, 1.5, and 2.2 nM for BRD2, BRD3, BRD4 and BRDT, respectively. |
| PC-27649 |
ARID1B inhibitor B-2
ARID1B inhibitor
|
ARID1B inhibitor B-2 is a selective small moelcule inhibitor of ARID1B, a subunit of the BRG1 (BRM)-associated factors (BAF) complex, binds to ARID1B DNA-binding domain. |
| PC-27364 |
KI-T28-03
TRIM28 inhibitor
|
KI-T28-03 is a selective small-molecule TRIM28 inhibitor that binds the TRIM28 PHD-bromodomain with ITC KD of 5 uM for full-length human TRIM28 protein, impairs leukemia cell proliferation and drives myeloid differentiation. |
| PC-27353 |
CZL-105
p300/CBP inhibitor
|
CZL-105 is a potent, selective and orally active p300/CBP bromodomain inhibitor, while sparing BET and demonstrates strong antiproliferative potency in OPM-2 multiple myeloma cells. |
| PC-27182 |
BRGi-39
BRG1 inhibitor
|
BRGi-39 (Z448047898) is a selective inhibitor of switch/sucrose non-fermentable (SWI/SNF) complex core ATPase subunit BRG1, blocks BRG1-BRD with exceptional selectivity and high affinity. |
| PC-27090 |
DUX4 inhibitor C06
DUX4 inhibitor
|
DUX4 inhibitor C06 is a potent, specific repressor of DUX4 and DUX4 target gene expression, exhibits binding to BAZ1A in vitro, also inhibits multiple kinases, including p38α, an upstream activator of DUX4. |
| PC-26728 |
UMB298
CBP/P300 inhibitor
|
UMB298 is a potent, selective CBP/P300 inhibitor with IC50 of 72 nM (CBP), Kd of 315 nM and 215 nM for CBP and EP300, shows 72-fold selectivity over BRD4. |
| PC-26723 |
FRC-303
CHD1 inhibitor
|
FRC-303 (CHD1 inhibitor 2s) is a selective small molecule CHD1 chromodomain inhibitor, targets the H3K4me3 binding site of tandem chromodomain (tCD) with Kd of 0.14 uM. |
| PC-26722 |
FRC-222
CHD1 inhibitor
|
FRC-222 (CHD1 inhibitor 2n) is a selective small molecule CHD1 chromodomain inhibitor, targets the H3K4me3 binding site of tandem chromodomain (tCD) with Kd of 0.15 uM. |
